Stochastic Modeling and Optimal Control of HIV-1 Infection Dynamics Under Combination Antiretroviral Therapy
by Yiping Tan, Suli Liu, Yongli Cai, Xiaodan Sun, Ruoxia Yao, Daihai He, Zhihang Peng, and Weiming Wang
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Within-host HIV-1 dynamics under cART exhibit persistent fluctuations driven by environmental noise. We develop a stochastic differential equation model to show that this noise decisively influences viral suppression versus persistence. Through optimal control theory, we compare strategies of cART intensification, immune modulation, and their combination. A cART-dominated, immune-assisted approach proves most effective, ensuring rapid viral suppression and cost-efficiency. This study offers a theoretical framework for optimizing HIV-1 treatment protocols.
Stochastic Modeling and Optimal Control of HIV-1 Infection Dynamics Under Combination Antiretroviral Therapy
