Modeling the effects of a Shock-and-Kill Treatment for HIV: Latency-Reversing Agents and Natural Killer Cells
by Guyue Liu, Suli Liu, Chiyu Zhang, Xu Chen, Wenxuan Li, and Huilai Li
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Despite ART's success in suppressing HIV, viral reservoirs persist as barriers to cure. This study leverages a mechanistically grounded mathematical model, calibrated with HIV-1-infected humanized mice data via Bayesian MCMC, to decode how tripartite therapy (ART + LRAs + NK cells) eradicates reservoirs.
Key findings:
(1) NK cells are pivotal modulators - their infusion frequency and dosage critically determine cure likelihood.
(2) The tripartite therapy offers superior viral suppression and accelerated therapeutic effects, with a specific parameter region for achieving a cure of HIV.
Graphical Abstract.
