The Society for Mathematical Biology is governed by its Officers and Board of Directors, elected by the membership. The Bylaws provide regulatory procedures to govern the Society.
Officers:
 President (2019–2021) Alexander Anderson Moffitt Cancer Center |
 Immediate past president – serving as vice president (2018-2020) Denise Kirschner University of Michigan |
 Secretary (2017-2020) Ping Ye South Dakota State University |
 Treasurer(2017-2020) Anna Mummert Marshall University |
Board Directors:
 (2016–2020) Ruth Baker University of Oxford |
 (2016–2020) Janet Best Ohio State University |
 (2018-2022) Peter Kim University of Sydney |
 (2018-2022) Doron Levy University of Maryland |
 (2018-2022) Elissa Schwartz Washington State University |
 (2016-2020) Amber Smith University of Tennessee Health Science Center |