The Society for Mathematical Biology is governed by its Officers and Board of Directors, elected by the membership. The Bylaws provide regulatory procedures to govern the Society.
Officers:
 President (2021–2023) Heiko Enderling Moffitt Cancer Center |
 Immediate Past President – serving as vice president (2021-2022) Alexander Anderson Moffitt Cancer Center |
 Secretary (2020-2023) Gibin Powathil Swansea University |
 Treasurer (2020-2023) Jana Gevertz The College of New Jersey |
Board of Directors:
 (2016–2024) Ruth Baker University of Oxford |
 (2020–2024) Zhilan Feng Purdue University |
 (2018-2022) Peter Kim University of Sydney |
 (2018-2022) Doron Levy University of Maryland |
 (2018-2022) Elissa Schwartz Washington State University |
 (2016-2024) Amber Smith University of Tennessee Health Science Center |